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Y. Hsieh
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P3.01 - Poster Session/ Treatment of Advanced Diseases – NSCLC (ID 208)
- Event: WCLC 2015
- Type: Poster
- Track: Treatment of Advanced Diseases - NSCLC
- Presentations: 1
- Moderators:
- Coordinates: 9/09/2015, 09:30 - 17:00, Exhibit Hall (Hall B+C)
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P3.01-046 - Pleural Photodynamic Therapy in Pleural Metastasis by Lung Cancer (ID 1129)
09:30 - 09:30 | Author(s): Y. Hsieh
- Abstract
Background:
Pleural metastasis is difficult to treat in malignancies, especially in lung cancer. Currently, the options of management of pleural metastasis include chemotherapy, operation with pleurectomy, or/and photodynamic therapy. Photodynamic therapy is a method utilizing photosensitizer to locate the site of tumor, and the tumor is exposed to the light after performing pleurectomy. Literature had reported successfully treatment of malignant mesothelioma by photodynamic therapy, a new approach for pleural malignancy dissemination. However, little was known about the result when in lung cancer.
Methods:
Between 2005 and 2015, we retrospectively reviewed the clinical characteristics, operative methods, and treatment outcomes of 25 patients with lung cancer with pleural seeding.
Results:
The mean patient age was 51.6 ± 10.7 years. There is no procedure-related mortality. Using Kaplan-Meier survival analysis, 3-year survival rate and 5-year survival rate was reached 71.8% and 59.3%, respectively. We compared the PDT lung cancer patients with those receiving chemotherapy or target therapy (n=51) and found that the PDT group had better survival than non-PDT patients (mean survival time: 42.8 versus 17.6 months; P=.041).
Conclusion:
With proper patient selection, photodynamic therapy of pleural dissemination in patients with lung cancer is feasible and associated with a good survival rate
