Author of

• 14661

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  P2.08 - Poster Session/ Thymoma, Mesothelioma and Other Thoracic Malignancies (ID 225)

  • Event: WCLC 2015
  • Type: Poster
  • Track: Thymoma, Mesothelioma and Other Thoracic Malignancies
  • Presentations: 1
  • Moderators:
  • Coordinates: 9/08/2015, 09:30 - 17:00, Exhibit Hall (Hall B+C)

  • 14696

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    P2.08-035 - Thymoma in Persahabatan Hospital Jakarta, Indonesia 2007 - 2012: An Observational Study (ID 2494)

    09:30 - 09:30  |  Author(s): E. Syahruddin
    • Abstract

    Background:
    In general Indonesian population, mediastinal tumors are rare. However In Persahabatan Hospital Jakarta as National Refferal Hospital in Respiratory Diseases, mediastinal tumors are ranked second in thoracic malignancy after lung cancer, and thymomas are common type.
    
    Methods:
    An observational study was done in patients diagnosed as thymoma in Persahabatan Hospital between 2007-2012. Clinical stages, histological types, treatment modalities and survival were analyzed. Histological classification were done based on World Health Organization criteria, and stage of the diseases was determined by Mosaoka Staging System.
    
    Results:
    We found that the trend of thymoma cases was increased annually since 2007 to 2012 in Persahabatan hospital Jakarta Indonesia. Among 67 cases diagnosed with thymoma, 43 cases has a complete data and follow up, of which 30 cases were male (69.8%) and 13 female (30.2%) with median age 50 years old ( range 16 years old to 79 years old). Myastenia gravis were found in 23 of 43 cases (53.5%). During follow up, 1-year survival rate was 72.1% and 3-year survival rate was 58,1 % respectively. There was no significant difference in survival rate of thymoma based on age, gender and the presence of myasthenia gravis, but Masaoka Staging and histological type were corellated with the survival. Using the Log-Rank test comparisons, We found statistically significant differences between type A-B2 (p 0.009), type A-C (p 0.001), type AB-C (p 0.032) and type B1-C (p 0.018). Masaoka staging has significant differences between stage I - IV A (p 0.012), the I - IV B (p 0.007), II-IV A (p 0.002) and II-IV B (p 0.002). Multivariate analysis showed that the most influential factor on the survival rate in these series was staging,-based on Masaoka Staging system.
    
    Conclusion:
    The Masaoka staging system is the most important determinant of survival in surgically cases of thymoma.