Author of

• 14661

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  P2.08 - Poster Session/ Thymoma, Mesothelioma and Other Thoracic Malignancies (ID 225)

  • Event: WCLC 2015
  • Type: Poster
  • Track: Thymoma, Mesothelioma and Other Thoracic Malignancies
  • Presentations: 1
  • Moderators:
  • Coordinates: 9/08/2015, 09:30 - 17:00, Exhibit Hall (Hall B+C)

  • 14683

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    P2.08-022 - Pulmonary Resection of Metastatic Renal Cell Carcinoma (ID 3043)

    09:30 - 09:30  |  Author(s): Y. Kondratsky
    • Abstract

    Background:
    Pulmonary resection for metastases from renal cell carcinoma (mRCC) is a treatment option that can provide long-term disease-free survival. Larger number and size of metastatic nodules, increasing number of lymph node metastases, shorter disease-free interval, and decreased preoperative forced vital capacity are negative prognostic factors in this setting. The potential role of surgery is illustrated by the results from a series of 278 patients with mRCC in which 51 percent underwent removal of all of their metastatic disease with curative intent, 25 percent underwent partial resection of their metastatic disease, and 24 percent were treated without surgery. Metastases were most frequently resected from the lung, brain, bone and soft tissue.
    
    Methods:
    Between 1989 and 2014, 73 patients (44 men, 29 women) underwent pulmonary resection of mRCC. Only patients who met the criteria for potentially curative operation, that means, control of primary tumor, ability to resect metastatic diseas were included. All patients received immunotherapy after surgical treatment.
    
    Results:
    Pulmonary metastases were bilateral in 15 patients and unilateral in 58 patients. 15 bilateral (9 staged) and 58 unilateral thoracotomies were performed. Wedge resection was performed in 68 and lobectomy in 5 patients. The overall 5-year survival was 72.8 % 10-year survival was 43,9% and 15-year survival was 20,9% among the patients, who had no other extrapulmonary metastases. The 5-year survival of curative resected patients with metachronous metastases was better then patiens with synchronous metastases. The overall 5-year survival was 31,3 % among the patients, who had extrapulmonary metastases.
    
    Conclusion:
    Surgical resection of isolated lung metastases in carefully selected patients is safe and effective. Metastasectomy nowadays is the best treatment option in cases with technical resectable metastases with as much as possible good prognostic factors.