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A. Kopitopoulou
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P2.07 - Poster Session/ Small Cell Lung Cancer (ID 222)
- Event: WCLC 2015
- Type: Poster
- Track: Small Cell Lung Cancer
- Presentations: 1
- Moderators:
- Coordinates: 9/08/2015, 09:30 - 17:00, Exhibit Hall (Hall B+C)
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P2.07-016 - Prognostic Impact of Bone Metastases in Small Cell Lung Carcinoma (ID 110)
09:30 - 09:30 | Author(s): A. Kopitopoulou
- Abstract
Background:
Metastatic bone disease is associated with increased morbidity as it may cause disabling pain and lead to other skeletal-related events (SREs), such as pathologic fractures, spinal cord compression or hypercalcemia of malignancy, with significant consequences on quality of life and overall functioning of patients, potentially affecting survival as well. The aim of the present study was to further explore the potential impact of bone metastases (BMs) and their therapeutic management on the overall prognosis of patients with small cell lung carcinoma (SCLC).
Methods:
A retrospective analysis of medical records of 363 patients with SCLC was performed. Clinicopathological features and survival data were correlated with the presence of BMs, their time point of development (early versus late onset) and their treatment modality (radiotherapy, bisphosphonates or both), in the entire study population and in the subgroups of patients with limited or extensive-stage disease (LD or ED-SCLC, respectively) at diagnosis.
Results:
Overall, 35.8% of our patients were diagnosed with BMs, either at diagnosis (early onset BMs, 26.7%) or at a subsequent time point (late onset BMs, 9.1%). Patients with early onset BMs had a worse survival time compared to those with late-onset BMs or those without BMs (log rank test, p=0.020; figure 1). No statistically significant associations were observed between OS and the presence of BMs in the ED and LD subgroups of patients (p=0.926 and p=0.144, respectively). Treatment modality of BMs had no impact on OS either (p>0.05). Multiple Cox regression analysis showed that increased age, poor performance status, presence of BMs and early onset BMs were independently associated with reduced OS. Figure 1
Conclusion:
The presence of early-onset BMs may represent an independent prognostic factor in patients with SCLC. In contrast, the type of modality employed for treatment of BMs had no statistically significant impact on survival in our study population.
