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A. Doboszyńska
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P2.06 - Poster Session/ Screening and Early Detection (ID 219)
- Event: WCLC 2015
- Type: Poster
- Track: Screening and Early Detection
- Presentations: 1
- Moderators:
- Coordinates: 9/08/2015, 09:30 - 17:00, Exhibit Hall (Hall B+C)
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P2.06-022 - Multiple Primary Malignancies - A Retrospective Analysis (ID 329)
09:30 - 09:30 | Author(s): A. Doboszyńska
- Abstract
Background:
With the increase in survival of cancer patients over the past three decades, both as a result of improved treatments and earlier diagnosis, the likelihood of developing a second cancer has increased. The aim of our study was to assess the frequency of multiple malignancies in patients hospitalised at the Centre for Pulmonary Diseases in Olsztyn, Poland.
Methods:
We performed a retrospective review of medical records of 1112 patients hospitalised at our Centre between January 2013 and September 2014. We selected cases with at least two malignancies. We recorded the number and locations of the tumours in the patients and their relatives, risk factors and co-morbidities. The inclusion criteria were met by 56 patients (18 women and 38 men).
Results:
Among the patients with multiple primary neoplasms we identified 52 cases where at least one of the primary cancers was lung cancer and 4 cases where none of the primary cancers was lung cancer. The mean age at diagnosis of the first and the second cancer was 62,16 (SD 12,04) years an 67,20 (SD 9,68) years, respectively. The mean interval between the diagnosis of the first and the second cancer was 3,84 (SD 13,03) years. We identified 4 cases of triple primaries and 1 case of quadruple primaries. Regarding the sequence of diagnosis, lung cancer was the first malignancy in 11 cases (1 - non-small-cell carcinoma, 4 - adenocarcinoma and 5 - squamous cell carcinoma, 1 - undiagnosed), the second malignancy in 39 cases (4 - non-small-cell carcinoma, 12 - adenocarcinoma, 10 - squamous cell carcinoma, 7 - small-cell carcinoma and 6 - undiagnosed) and the third malignancy in 2 cases (1 - squamous cell carcinoma, 1- undiagnosed). The other malignancies diagnosed as the first ones and the second ones were:
We identified the following co-morbidities: hypertension (28), COPD (17), coronary artery disease (8), atrial fibrillation (6), myocardial infarction (3) type 2 diabetes mellitus (4), thyroid diseases (4), chronic renal failure (2), peripheral artery disease (1), stroke (1) and connective tissue disease (1).First Second Prostate cancer 6 4 Breast cancer 5 2 Vocal cord cancer 1 1 Renal cel carcinoma 4 1 Uterine cancer 4 0 Colorectal cancer 8 0 Skin cancer 3 0 Bladder cancer 2 3 Adrenal cancer 2 1 Lymphoma 1 3 Laryngeal cancer 3 0 Gastric cancer 1 1 Brain cancer 2 0 Tongue cancer 1 0 Salivary gland cancer 1 0 Ovarian cancer 1 0 Thyroid cancer 0 1
Conclusion:
· Lung cancer occur more frequently as the second malignancy. · Patients with multiple neoplasms make up 5,04% of all patients with lung cancer and the number seems to increase. · Generally synchronous neoplasms occur later (medium age; 67,31; SD 11,64), while metachronous neoplasms occur earlier (medium age of the first cancer: 60,12; SD 11,55 and the second one 67,17; SD 9,15), p=0,0014.
