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X. Zheng
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P2.06 - Poster Session/ Screening and Early Detection (ID 219)
- Event: WCLC 2015
- Type: Poster
- Track: Screening and Early Detection
- Presentations: 1
- Moderators:
- Coordinates: 9/08/2015, 09:30 - 17:00, Exhibit Hall (Hall B+C)
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P2.06-021 - Analysis of Autofluorescence Bronchoscopy Used for Characterisation and Identification of Bronchopulmonary Cancer (ID 1169)
09:30 - 09:30 | Author(s): X. Zheng
- Abstract
Background:
The aim of the study is to introduce a more effective quantitative method(optimal identification index and reference value) for characterizing the AFB images within the region of interest and to explore the value of AFB in diagnosis of different types of lung cancer.
Methods:
Patients with one or more preinvasive bronchial lesions were entolled, followed-up by white light bronchoscope(WLB) and AFB. A quantitative analysis based on color space(red-to-green value, R/G value) was conducted and the result was compared with the final diagnosis obtained by the pathology of biopsy and/or by surgical pathology.
Results:
A retrospective analysis was conducted on 218 cases with 1,208 biopsies. 173 cases were diagnosed as positive by WLB associated with AFB, which included 151 true positive cases and 22 false positive cases. There were 45 cases in 151 true postive cases which included 13 false negative cases and 32 true negative cases. WLB associated with AFB was able to differentiate between benign and malignant lesion lymph nodes with a high sensitivity, specificity, positive predictive value and negative predictive value(92.1%, 59.3%, 87.3% and 71.1%, respectively). The quantitative method of R/G value allowed an more excellent discrimination and yielded a high sensitivity and specificity(82.3% and 80.5%), based on a cut-off level of 1.485.
Conclusion:
AFB associated with WLB is a promising method which allows characterisation and differentiation of benign and malignant lesions with a high sensitivity, specificity based on R/G value.
