Virtual Library
Start Your Search
H. Kim
Author of
-
+
P2.03 - Poster Session/ Treatment of Locoregional Disease – NSCLC (ID 213)
- Event: WCLC 2015
- Type: Poster
- Track: Treatment of Locoregional Disease – NSCLC
- Presentations: 1
- Moderators:
- Coordinates: 9/08/2015, 09:30 - 17:00, Exhibit Hall (Hall B+C)
-
+
P2.03-037 - Prognostic Factors in Pathologic N2 Non-Small Cell Lung Cancer (ID 3193)
09:30 - 09:30 | Author(s): H. Kim
- Abstract
Background:
Mediastinal lymph node metastasis is one of the strong prognostic factors in non-small cell lung cancer (NSCLC). Pathologic N2 patients group is heterogenous group consists of stage IIIA to stage IV. Moreover owing to difficulty in preoperative prediction of N2 disease, pathologic N2 patients group shows more variable in clinical stage. We tried to figure out which factors make difference in prognosis of N2 patients.
Methods:
Between May 2003 and December 2013, total 1994 patients underwent pulmonary resection surgery due to lung cancer. Only pathologically proven N2 patients were included in the study. Among them, patients with small cell lung cancer, double primary lung cancer and other malignant disease were excluded. Therefore, 195 N2 patients were analyzed for the study. The patients' clinical information was collected from prospectively recorded database and analyzed retrospectively. Regional N2 disease was defined as upper mediastinal LN involvement for upper lobar disease and lower mediastinal LN involvement for lower lobar disease. Extended N2 disease was defined as involvement of non-regional N2 station.
Results:
Figure 1Mean follow up duration was 41 months and 5 year survival rate was 50% for the study population. As postoperative stage, majority of the study group was IIIA (84%). Patients' clinical stage and clinical T stage did not make difference in survival and recurrence. However clinical N0 group showed superior result in survival (p<0.001) and recurrence (p=0.46) even in same stage. In metastatic mediastinal LN extent analysis, extended N2 disease made worse survival than regional N2 disease (p=0.04). Total number of metastatic LN did not make any difference in prognosis.
Conclusion:
Owing to heterogeneity, even in same stage group, pathologic N2 patients have showed different prognosis. In this study, we confirmed that clinical N0 was relatively good prognostic factor and extended N2 disease was bad prognostic factor. Deciding postoperative treatment plan, we should take account of these factors. Also, the survival difference between regional and extended N2 disease might be considered in staging revision of NSCLC.
