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D. Harada
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P2.03 - Poster Session/ Treatment of Locoregional Disease – NSCLC (ID 213)
- Event: WCLC 2015
- Type: Poster
- Track: Treatment of Locoregional Disease – NSCLC
- Presentations: 1
- Moderators:
- Coordinates: 9/08/2015, 09:30 - 17:00, Exhibit Hall (Hall B+C)
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P2.03-020 - Radical Lung Resection after Curative Chemoradiotherapy for Locally Advanced Lung Cancer (ID 2668)
09:30 - 09:30 | Author(s): D. Harada
- Abstract
Background:
The safety and perioperative complications of radical pulmonary resection after concurrent chemoradiotherapy (CRT) for locally advanced lung cancer (LALC) have been problematic.
Methods:
We retrospectively evaluated 16 patients who received CRT and radical surgical resection for locally advanced lung cancer from May 2008 to April 2015. The treatment for LALC consisted of cisplatin and drugs (Docetaxel, Vinorelbine, or TS-1) with curative concurrent thoracic radiotherapy (60Gy.).
Results:
Figure 1 The mean age at the surgery was 61 years (range 46- 71 years), one woman and 15 men. The mean interval from CRT to the surgery was 19 months (range 3-96 months). All patients except one case underwent complete surgical resection with mediastinal nodal dissection including lobectomy in 11 cases, lobectomy with bronchoplasty in 2 cases, pneumonectomy in, 2 cases, and segmentectomy in one case. The bronchial stump was covered with pericardial fat tissue or intercostal muscle. Histological type was adenocarcinoma in 9 cases, squamous carcinoma in 4 cases, large-cell-carcinoma in 2 cases, and combined cell type small-cell carcinoma in one case. The mean operation time was 301 minutes (range 163-649 minutes), and mean blood loss was 842g (range 90-6000g). There was no operative mortality and three cases post-operative morbidity such as arrhythmia in 2 cases, atelectasis in 2 cases, pneumonia and heart failure in each. There was no broncho-pleural fistula or bronchial dehiscence. The 3 and 5 years survival after surgical resection was 70 % and 70 % with 39 months median follow-up period.
Conclusion:
Radical pulmonary resection after curative concurrent chemoradiotherapy for LALC is feasible in careful patient selection, operative procedure and meticulous perioperative care.
