Virtual Library
Start Your Search
E. Brandén
Author of
-
+
P2.02 - Poster Session/ Treatment of Localized Disease – NSCLC (ID 210)
- Event: WCLC 2015
- Type: Poster
- Track: Treatment of Localized Disease - NSCLC
- Presentations: 1
- Moderators:
- Coordinates: 9/08/2015, 09:30 - 17:00, Exhibit Hall (Hall B+C)
-
+
P2.02-041 - Stereotactic Body Radiotherapy (SBRT) or Surgery in Early Stage (I & II) Non Small Cell Lung Cancer (NSCLC) (ID 1621)
09:30 - 09:30 | Author(s): E. Brandén
- Abstract
Background:
For patients with NSCLC clinical stages I and II disease with no medical contraindications, surgery is treatment of choice showing 5-year survival rates of about 60–80% for stage I and 40–50% for stage II, respectively. However, for patients who are medically or technically unfit for surgery and for patients refusing surgery, SBRT) is an alternative with local control rates >90% at 3 years.
Methods:
Medical journals in all patients with stage I or II NSCLC who were underwent surgery and treated with SBRT at the Department of oncology or thoracic surgery, Karolinska University Hospital, Sweden from 2003 to 2009 were retrospectively reviewed.
Results:
In all, 186 (78.2%) underwent surgery and 52 (21.8%) were treated with SBRT. Mean, median and range of age among the surgery group was 69.29, 70.52 and 45-85 years, while in the SBRT group, these figures were 78.04, 80.03 and 61-89 years. The difference in age between the groups was significant (p=0.03).There were significantly more comorbidites in the SBRT group. Among the surgery group, 91.3% were smokers or former smokers. The figures for SBRT group was 94.1%. There was a significant difference in performance status (PS) between the groups (p<0.001) with with PS 0-1 in 98.9% in the surgery group compared with 69.2% in the SBRT group. There was a significant difference in lung function with mean FEV1 2.15 liter in surgery group compared to 1.45 in the SBRT group. The figures for mean FEV1% was 83% respectively 57.5%. The median overall survival was 97 months for the surgery group and 61.8 months for the SBRT group (p<0.001).
Conclusion:
The much worse median overall survival in the SBRT group can be explained by the selection of patients, but still, a survival of more than 5 years in an elderly group with so many comorbidities and a bad PS indicates that SBRT has been of value.
