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X. Zhai



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    P2.02 - Poster Session/ Treatment of Localized Disease – NSCLC (ID 210)

    • Event: WCLC 2015
    • Type: Poster
    • Track: Treatment of Localized Disease - NSCLC
    • Presentations: 1
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      P2.02-035 - Is There an Optimal Time to Initiate Adjuvant Chemotherapy in Order to Predict the Benefit of Survival in Non-Small Cell Lung Cancer? (ID 2341)

      09:30 - 09:30  |  Author(s): X. Zhai

      • Abstract
      • Slides

      Background:
      Adjuvant chemotherapy (ACT) improves the survival for completely resected non-small cell lung cancer (NSCLC) patients. However, there are very few reports to explore the correlation between time of initiation of adjuvant chemotherapy (TTAC) and survival.

      Methods:
      208 completely resected NSCLC patients received adjuvant chemotherapy in Cancer Hospital, Chinese Academy of Medical Sciences from 2001-2010 were analyzed. TTAC was measured from the date of surgery to initiation of ACT. Disease-free survival (DFS) was defined as the duration from the surgery to the time of relapse or last follow-up. Optimal cutoff value of the TTAC was determined by maximally selected log-rank statistics. Survival analysis was performed using Kaplan–Meier estimates, log-rank tests and Cox’s proportional hazards regression analysis. Propensity score matching (PSM) was used, and a survival analysis of the match data was carried out.

      Results:
      The best discriminating cutoff value of TTAC was the 50th day(Figure 2). According to the cutoff value of 50, patients were divided into 2 groups, group1 (≤50days, n=183) and group2 (>50 days, n=25). Figure 1 shows the baseline characteristics of the two groups of patients before and after PSM .There was significant difference in DFS between the two groups (mDFS: 737days vs. 369days, P=0.005)(Figure 2), and the TTAC was found to be a significant predictive factor for DFS in multivariable analysis (P =0.035).Unfortunately, DFS was not continually significant difference in 22 PSM pairs (mDFS:576days vs. 369days,P=0.122) (Figure 2).Figure 1Figure 2





      Conclusion:
      TTAC does not appear to be associated with DFS in NSCLC. The conclusion was limited by the small sample size; therefore the number of patients between the groups was not close. Larger sample of cases should be warranted in future.

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    P3.02 - Poster Session/ Treatment of Localized Disease – NSCLC (ID 211)

    • Event: WCLC 2015
    • Type: Poster
    • Track: Treatment of Localized Disease - NSCLC
    • Presentations: 1
    • +

      P3.02-032 - Effect of Age on Adjuvant Chemotherapy after Resection of Non-Small Cell Lung Cancer (ID 2343)

      09:30 - 09:30  |  Author(s): X. Zhai

      • Abstract
      • Slides

      Background:
      Adjuvant chemotherapy (ACT) improves the survival for completely resected non-small cell lung cancer (NSCLC) patients. However, there are few reports to explore the effect of age on the efficacy of adjuvant chemotherapy of NSCLC after surgery.

      Methods:
      Patients received adjuvant chemotherapy after surgery in Cancer Hospital, Chinese Academy of Medical Sciences from 2001-2010 were analyzed. Disease Free Survival (DFS) of the two groups of patients was compared in terms of their age. Survival analysis was performed using Kaplan–Meier estimates, log-rank tests and Cox’s proportional hazards regression analysis. Propensity score matching (PSM) was used, and a survival analysis of the match data was carried out.

      Results:
      The data of 256 patients with stage I to stage Ⅲ NSCLC who underwent completely resection was analyzed. Those two groups,patients aged≤65 years (27~65, n=206) and patients aged>65 years (66~72, n=50) ,were compared. Figure 1 shows the baseline characteristics of the two groups of patients before and after PSM. There was no significant difference in DFS between the two groups (mDFS: 594 days vs. 554 days, P=0.951) (Figure 2), and the age was not associated with DFS in multivariable analysis (P =0.602). DFS was continually not significant difference in 40 PSM pairs (mDFS: 600 days vs. 554 days, P=0.731) (Figure 2).Figure 1Figure 2





      Conclusion:
      The results suggest that older patients do not appear a shorter DFS than younger. Thus, elderly patients should not be denied adjuvant chemotherapy based merely on age. The conclusion was limited by the small sample size; moreover, the number of patients between the groups was not close. Larger sample of cases should be warranted in future.

      Only Active Members that have purchased this event or have registered via an access code will be able to view this content. To view this presentation, please login or select "Add to Cart" and proceed to checkout.