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S. Uematsu



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    P2.02 - Poster Session/ Treatment of Localized Disease – NSCLC (ID 210)

    • Event: WCLC 2015
    • Type: Poster
    • Track: Treatment of Localized Disease - NSCLC
    • Presentations: 1
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      P2.02-007 - Correlation Between Histological Invasiveness and CT Value in Pure GGNs (ID 271)

      09:30 - 09:30  |  Author(s): S. Uematsu

      • Abstract
      • Slides

      Background:
      The purpose of this study is to evaluate the correlation between histological invasiveness and computed tomography (CT) value and size in pure ground glass nodules (GGNs) to determine optimal “follow-up or resection” strategies.

      Methods:
      Between 2001 and 2014, 78 resected pure GGNs were evaluated retrospectively. Maximum diameter and CT value of pure GGNs were measured using a computer graphics support system.

      Results:
      All GGN with a maximum diameter ≦10mm and CT value ≦-600 Hounsfield units (HU) were noninvasive lesions, while 21 of 26 (81%) with a maximum diameter >10 mm and CT value >-600 HU were invasive lesions. With respect to a correlation between each histological type and pure GGN with a maximum diameter ≦10 mm and CT value ≦-600 HU, the specificity was 90% and the sensitivity and negative predictive value were both 100% in atypical adenomatous hyperplasia (AAH), while the specificity was 58% and the sensitivity and positive predictive value were 0% in minimally invasive and invasive adenocarcinoma.

      Conclusion:
      In establishing follow-up criteria for pure GGNs at a maximum diameter of ≦10mm and CT value of ≦-600HU, unnecessary surgery for AAH and therapeutic delay for invasive adenocarcinoma can be avoided.

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