Virtual Library

Start Your Search

A. Zur Hausen



Author of

  • +

    P1.08 - Poster Session/ Thymoma, Mesothelioma and Other Thoracic Malignancies (ID 224)

    • Event: WCLC 2015
    • Type: Poster
    • Track: Thymoma, Mesothelioma and Other Thoracic Malignancies
    • Presentations: 1
    • +

      P1.08-033 - pRb and p16INK4 in Human Thymic Epithelial Tumors in Relation to Human Polyomavirus 7 (ID 249)

      09:30 - 09:30  |  Author(s): A. Zur Hausen

      • Abstract
      • Slides

      Background:
      We have recently reported the presence of the Human polyomavirus 7 (HPyV7) in human thymic epithelial tumors as assessed by diverse molecular techniques. Here we report on the co-expression of p16, retinoblastoma protein (pRb) and phosphoralized retinoblastoma protein (phospho-Rb) in human thymic epithelial tumors in relation to HPyV7.

      Methods:
      PRB, phospho-RB and p16 expression was assessed by immunohistochemistry in 37 thymomas and 2 thymic carcinomas. 17 thymomas (46%) and 1 thymic carcinoma (50%) were recently tested positive for HPyV7. In addition, 20 follicular hyperplasias were tested.

      Results:
      Expression of pRb was observed in 35 thymomas (94.6%), in 16 thymomas (43.2%) the expression was strong. Phospho-Rb was observed in 31 thymomas (83.8%). 19 thymomas (51.4%) showed immunoreactivity for p16 of which 8 thymomas revealed very strong p16 expression. No p16 expression was detected in thymic carcinomas. In addition, no significant correlation between the presence of HPyV7 and pRb-, phospho-Rb- and p16-expression could be established. No correlation between pRb, phospho-Rb, p16 and WHO staging, Masaoka-Koga staging or the presence of MG was found. All 20 follicular hyperplasias showed expression of pRb and less expression of phospho-Rb.

      Conclusion:
      Although polyomaviruses have been shown to interact with cell cycle proteins no correlation between the presence of HPyV7 and the expression of pRb, phospho-Rb and p16 in human thymic epithelial tumors was observed. In as much HPyV7 contributes to human thymomagenesis remains to be established. Our data indicate pRb, phospho-Rb and p16 expression are rather unlikely to be involved in HPyV7 related thymomagenesis.

      Only Active Members that have purchased this event or have registered via an access code will be able to view this content. To view this presentation, please login or select "Add to Cart" and proceed to checkout.