Author of

• 13580

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  P1.04 - Poster Session/ Biology, Pathology, and Molecular Testing (ID 233)

  • Event: WCLC 2015
  • Type: Poster
  • Track: Biology, Pathology, and Molecular Testing
  • Presentations: 1
  • Moderators:
  • Coordinates: 9/07/2015, 09:30 - 17:00, Exhibit Hall (Hall B+C)

  • 13694

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    P1.04-114 - Effect of Interleukin-2 Treatment Combined with Magnetic Fluid Hyperthermia on Lewis Lung Cancer-Bearing Mice (ID 457)

    09:30 - 09:30  |  Author(s): R. Hu
    • Abstract
    • Slides

    Background:
    The study aimed to investigate the therapeutic effect of interleukin-2 (IL-2) treatment combined with magnetic fluid hyperthermia (MFH) on Lewis lung cancer-bearing mice.
    
    Methods:
    Magnetic fluids were prepared in vitro and directly injected into the tumors in the mice, which were subjected to an alternating magnetic field. The temperature in the tumor reached 43°C and was maintained by controlling the strength of magnetic field for 30 minutes. Twenty-four hours later, IL-2 was injected directly into the tumors. Mice were divided into four groups: group I (control), group II (MFH), group III (IL-2), and group IV (IL-2+MFH).
    
    Results:
    The tumor grew gradually in group II and group IV (both P<0.05) compared to the control group. Histological analysis showed that the tumor cells underwent apoptosis and necrosis. Immunohistochemistry results demonstrated that heat shock protein 70 (HSP70) and CD8-positive T cells were strongly expressed.
    
    Conclusion:
    The results have provided evidence that IL-2 treatment combined with MFH could improve the therapeutic effect on lung cancer-bearing mice
    
    

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