Virtual Library

Start Your Search

Q. Luo



Author of

  • +

    P1.04 - Poster Session/ Biology, Pathology, and Molecular Testing (ID 233)

    • Event: WCLC 2015
    • Type: Poster
    • Track: Biology, Pathology, and Molecular Testing
    • Presentations: 1
    • +

      P1.04-081 - Expression of PPAR-γ Ligand in Lung Cancer and Its Effect on the Apoptosis of Lung Cancer (ID 1472)

      09:30 - 09:30  |  Author(s): Q. Luo

      • Abstract
      • Slides

      Background:
      To explore the expression of PPAR-γ ligand in lung cancer and its effect on the apoptosis of lung cancer.

      Methods:
      The expression of PPAR-γ in 80 patients with lung cancer was detected using cell-culture method and its expression in the lung cancer cell lines was also determined by RT-PCR and Western blot. Additionally, TUNEL method was used to detect the apoptosis.

      Results:
      PPAR-γ was expressed in the lung cancer tissue and the tissue of lung benign lesions. Its optical density was the highest in the lung cancer tissue (0.1832±0.0407), then the tissue of lung benign lesions (0.1201±0.0308), and the lowest in the normal tissue (0.1185±0.0296). The total expression of PPAR-γ showed significant difference in the patients with different pathological types and differentiated degrees (P<0.05), and there was also statistical significance regarding the total expression of PPAR-γ in small cell lung cancer and non-small cell lung cancer (P<0.01). The expression of squamous cell carcinoma is the highest in non-small cell lung cancer. Significant difference was presented by comparison to the expression of PPAR-γ in poorly-differentiated and moderately, highly-differentiated lung cancer tissues (P<0.05).

      Conclusion:
      The expression of PPAR-γ is closely related to the pathological features of patients with lung cancer, and hence, to research PPAR-γ ligand can provide new evidences for the treatment of lung cancer.

      Only Active Members that have purchased this event or have registered via an access code will be able to view this content. To view this presentation, please login or select "Add to Cart" and proceed to checkout.