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D. Flieder



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    P1.04 - Poster Session/ Biology, Pathology, and Molecular Testing (ID 233)

    • Event: WCLC 2015
    • Type: Poster
    • Track: Biology, Pathology, and Molecular Testing
    • Presentations: 1
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      P1.04-039 - Ex-Vivo Artifacts and Histopathological Pitfalls in the Lung (ID 2602)

      09:30 - 09:30  |  Author(s): D. Flieder

      • Abstract
      • Slides

      Background:
      Surgical and pathological handling of lung physically affects lung tissue. This leads to artifacts that alter the morphological appearance of pulmonary parenchyma.

      Methods:
      In this study four mechanisms of ex-vivo artifacts and corresponding diagnostic pitfalls are described and illustrated.

      Results:
      The four patterns of artifacts are: 1) Surgical collapse, due to the removal of air and blood from pulmonary resections; 2) Ex-vivo contraction of bronchial and bronchiolar smooth muscle; 3) Clamping edema of open lung biopsies, and 4) Spreading of tissue fragments and individual cells through a knife surface. Morphologic pitfalls include diagnostic patterns of adenocarcinoma, asthma, constrictive bronchiolitis, and lymphedema.

      Conclusion:
      Four patterns of pulmonary ex-vivo artifacts are important to recognize, in order to avoid morphologic misinterpretations, possibly improving reproducibility in histopathological diagnosis of lung cancer

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