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J. Ferrando Marco
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P1.04 - Poster Session/ Biology, Pathology, and Molecular Testing (ID 233)
- Event: WCLC 2015
- Type: Poster
- Track: Biology, Pathology, and Molecular Testing
- Presentations: 1
- Moderators:
- Coordinates: 9/07/2015, 09:30 - 17:00, Exhibit Hall (Hall B+C)
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P1.04-006 - Prognostic and Predictive Role of KRAS-Mutations in Patients with Advanced Non-Squmous Non-Small-Cell Lung Cancer (NS-NSCLC) (ID 2548)
09:30 - 09:30 | Author(s): J. Ferrando Marco
- Abstract
Background:
KRAS is the most frequently mutated oncogene in lung adenocarcinoma patients. The prognostic rolo of mutatn-KRAS in lung adenocarcinoma is controversial, especially in non-asian populations. Studies also suggest the potencial predictive role of mutant-KRAS in the context of chemosensitivity of NSCLC. The aim of our study is to analyze the role of KRAS mutations as prognostic factor in advanced NSCLC, and their value as predictive biomarker of chemotherapy efficacy
Methods:
Retrospective study of patients with advanced NS-NSCLC in our institution between january-2013 and december-2014. Mutation analysis for KRAS was performed an the relation with overall survival was assessed. Secondary endpoints were its relation with progression-free survival and response to chemotherapy.
Results:
A total of 42 patients met inclusion criteria. Median age was 61.5 years. Thirty-three male (78.6%), 27 ECOG-PS 0-1 (64.3%), and 40 (95.2%) adenocarcinoma. Twenty-six patients (61.9%) received chemotherapy as first line treatment, 4 (9.5%) anti-EGFR treatment and 12 supportive care. Nine patients (21.4%) harboured KRAS mutations, all of them at exon 12. There were no differences in age, performance status or smoking history between patients with KRAS mutants vs those with wild-type tumours; instead KRASmut patients presented a higher rate of brain metastases (55.5 vs 20%; p=0.05) and higher number of methastatic locations at diagnosis (77.7 vs 41.3% of patients with more than one site of metastases). Median Overall Survival was superior for patients with wild type tumours (19 vs 10 months, p =0.22). There were no differences in response rate in patients treated with platinum doblet chemotherapy (Wild-type vs KRAS mut: 44.4 vs 33.3%, p=0.5), but progression free survival and overall survival were superior for wild-type tumour patients (PFS: 3 vs 15 months, p=0.001; OS: 10 vs NR, p=0.06)
Conclusion:
With the limitation of small numbers, our data suggest that KRASmut patients are a subgroup with poorer prognostic. Moreover, they seem to benefit less from standard chemotherapy based in platinum doublets.
