Author of

• 15382

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  P3.04 - Poster Session/ Biology, Pathology, and Molecular Testing (ID 235)

  • Event: WCLC 2015
  • Type: Poster
  • Track: Biology, Pathology, and Molecular Testing
  • Presentations: 1
  • Moderators:
  • Coordinates: 9/09/2015, 09:30 - 17:00, Exhibit Hall (Hall B+C)

  • 15501

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    P3.04-119 - The Decreased Serum Dopamine Level Is Associated with Poor Prognosis in Non-Small Cell Lung Cancer and Contributes to Cancer Cell Stemness (ID 741)

    09:30 - 09:30  |  Author(s): W. Zhao
    • Abstract

    Background:
    Lung cancer ranks the first cancer related mortality worldwide. Dysregulation of dopamine-related pathways have been implicated in tumor development/angiogenesis.
    
    Methods:
    In this study, we detected dopamine in 63 non-small cell lung cancer (NSCLC) patients, and 70 healthy control serum by Elisa kit. The associations between serum dopamine level with patient’s prognosis and survival were analyzed by SPSS 17.0 statistical software. Add dopamine into NSCLC cancer cell medium and FACS detected the effects on cancer cells stemness.
    
    Results:
    The serum dopamine level is significantly down-regulated in NSCLC samples, compared to the healthy control (P < 0.0001). In addition, low level of serum dopamine was correlated with tumor size (P = 0.0207) and N stage (P = 0.007). Kaplan-Meier analysis indicated that patients with low serum dopamine had a poor overall survival (P = 0.0144). Additional dopamine inhibited the stemness and proliferation of NSCLC cell line A549.
    
    Conclusion:
    Our data indicates that dopamine negatively regulates NSCLC cell stemness and might be a novel therapeutic target in NSCLC patients.