Author of

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  P3.24 - Poster Session 3 - Supportive Care (ID 160)

  • Event: WCLC 2013
  • Type: Poster Session
  • Track: Supportive Care
  • Presentations: 1
  • Moderators:
  • Coordinates: 10/30/2013, 09:30 - 16:30, Exhibit Hall, Ground Level

  • 12873

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    P3.24-020 - Case studies of mutidisciplinary treatment for Large Cell Neuroendocrine Lung Carcinoma (ID 1352)

    09:30 - 09:30  |  Author(s): M. Naruke
    • Abstract

    Background
    The World Health Organization (WHO) currently classifies Large Cell Neuroendocrine Lung Carcinoma (LCNEC) as a distinct subtype of pulmonary large cell carcinoma, however, the survival after surgical-resection of LCNEC appears to be substantially worse than for other Non-small cell carcinoma (NSCLC), resembling more the survival of small cell carcinoma. The question remains whether LCNEC is best treated the same as other NSCLC. The purpose of this study is to analyze the feasibility of the multidisciplinary treatment for LCNEC.

    Methods
    The records of 6 LCNEC (2.9%) out of 210 patients, who underwent an intended curative resection for lung cancer in our institute during a 10-year period beginning in 2002, were reviewed. The patients consisted of 6 male current smokers, with a median age of 68 years (63 – 82). The clinical stages were 2 in stage IB, 2 in stage IIA, 1 stage IIB and 1 stage IIIA. 5 patients underwent an anatomical resection. The rest of them underwent tumorectomy. 3 patients underwent not only pulmonary resection but also adjuvant chemotherapy for primary cancer. Median follow-up time was 37.5 months (15-81).

    Results
    The two patients with clinical stage IIA were upgraded to pathological stage IIIA after operation. Two of them, who were pathological stage IB and IIIA, died of pneumonia and secondary cancer without LCNEC recurrence 11 and 15 months after the operation. Recurrence of disease was observed in three patients with pathological stage IIB and IIIA. One of the patients died in 55 postoperative months after receiving adrenalectomy, chemotherapy and radiation therapy for 25 months for recurrent cancer. Two of the patients are still alive after receiving either surgery pus chemotherapy or radiation therapy for 32 months and 43months since undergoing initial treatment.

    Conclusion
    Multidisciplinary treatment should be considered as complementary technique to surgery for LCNEC and examined in larger trial.