Author of

• 12824

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  P3.21 - Poster Session 3 - Diagnosis and Staging (ID 171)

  • Event: WCLC 2013
  • Type: Poster Session
  • Track: Prevention & Epidemiology
  • Presentations: 1
  • Moderators:
  • Coordinates: 10/30/2013, 09:30 - 16:30, Exhibit Hall, Ground Level

  • 12829

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    P3.21-005 - Clinical characteristics of non-small cell lung cancer with EGFR mutations in never smokers (ID 1755)

    09:30 - 09:30  |  Author(s): S.K. Han
    • Abstract

    Background
    EGFR mutations are highly associated with pulmonary adenocarcinoma in East Asian never-smoker population. The aim of this study is to evaluate the clinical characteristics of non-small cell lung cancer (NSCLC) with EGFR mutations in never smokers.

    Methods
    From June 2011 to Dec 2012, consecutive NSCLC patients who admitted for initial diagnosis of lung cancer without smoking habit were recruited in Seoul National University Hospital.

    Results
    Among 979 of lung cancer patients, 342 never smokers with NSCLC (38.6%) were analyzed. Mean age was 62.7 ± 10.6 years old and mean BMI was 23.8 ± 3.0 kg/m[2]. Adenocarcinoma (307, 89.8%) was the major pathologic diagnosis. The most common clinical stage was IV (134, 39.2%), followed by stage Ia (115, 33.6%). Among 303 patients who underwent EGFR mutation test, 180 (59.4%) patients had EGFR mutations. The never smokers with NSCLC-EGFR (+) showed better performance status (P=0.006), lower uptake of SUV in main mass (8.9 ± 5.9 vs. 11.4 ± 6.8, P=0.003), early clinical stage (≤ II, P=0.009), and higher proportion of curative lung resection (63.3% vs. 41.2%, P=0.005) compared to the patients with NSCLC-EGFR (-).

    Conclusion
    EGFR mutations are associated with early stage of non-small cell lung cancer in never smokers.