Author of

• 12791

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  P3.19 - Poster Session 3 - Imaging (ID 181)

  • Event: WCLC 2013
  • Type: Poster Session
  • Track: Imaging, Staging & Screening
  • Presentations: 1
  • Moderators:
  • Coordinates: 10/30/2013, 09:30 - 16:30, Exhibit Hall, Ground Level

  • 12793

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    P3.19-002 - Fibrotic changes on low-dose chest CT as a risk factor of lung cancer development in subjects with asbestos exposure (ID 863)

    09:30 - 09:30  |  Author(s): N. Fujimoto
    • Abstract

    Background
    Asbestos is known for one of the risk factors of lung cancer (LC). The subjects with asbestos exposure are considered to have increased risk of LC especially if chest X-ray shows fibrotic changes of the lung. However, there are few reports about the association between the risk of LC and fibrotic changes detected by chest CT. The aim of this study was to define the specific CT findings of risk of LC among the subjects with asbestos exposure.

    Methods
    The low-dose chest CT(LD-CT) was taken as LC screening with written informed consent in subjects with former asbestos exposure in a prone position with the dose less than 30mAs. Each image was independently interpreted with more than two radiologists especially focused on fibrotic changes including subpleural curvilinear shadow/subpleural dots, reticular shadow, parenchymal band, traction bronchiectasis, and honeycombing. These findings were scored according to the extent. A chi square test was used to investigate the difference of categorical variables, and Mann-Whitney U test was applied as a non-parametric test.

    Results
    Between 2010 and 2012, chest LD-CT was taken in 2,126 subjects at 8 institutions in Japan. During the period, 38 (1.79%) LC was detected. We compared LC group and non-LC group, and there was no difference of duration of occupational asbestos exposure, or the prevalence of fibrotic changes on chest LD-CT. The extent of the fibrosis determined by scoring of the LD-CT findings, however, was more prominent in LC group than in non-LC group, though it was not statistically significant (p=0.067). On the other hand, LC developed more frequently in subjects with some fibrotic change (2.67%) than in those without any fibrotic change (1.44%, p=0.067).

    Conclusion
    The fibrotic changes of the lung detected on LD-chest CT might be the risk factor of LC development in subjects with former asbestos exposure. Further examination is planned with more subjects and longer period of observation.