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G. Gonzalez



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    P3.07 - Poster Session 3 - Surgery (ID 193)

    • Event: WCLC 2013
    • Type: Poster Session
    • Track: Surgery
    • Presentations: 1
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      P3.07-019 - Sex-Based Differernces in Morbidity and Mortality Associated with Non-Small Cell Lung Cancer Resections (ID 1708)

      09:30 - 09:30  |  Author(s): G. Gonzalez

      • Abstract

      Background
      Stage for stage, women have superior survival compared to men with non-small cell lung cancer (NSCLC). This includes women undergoing resection, but little is reported regarding sex-based differences in operative morbidity, mortality, and length of hospital stay (LOS) following NSCLC resection.

      Methods
      We retrospectively evaluated all patients undergoing primary NSCLC resections at our institution from 01/07-12/08 to evaluate the prognostic significance of female sex on morbidity, mortality and LOS.

      Results
      A total 259 patients were included, 155 females and 104 males. The majority of resections were lobectomy (162/259) and by VATS (161/259). Women were significantly younger (70.6 vs. 74.0 years, p=0.006), reported fewer pack years smoked (30 vs. 44 years, p=0.001), had more adenocarcinoma histology (86% vs. 63%, p<0.001) and had higher percent predicated forced expiratory volume in 1 second (FEV1%)(84 vs. 77, p=0.014) than men. No other significant differences in pre-treatment demographics, tumor characteristics or surgical procedures were noted. A significantly reduced rate of post operative atrial fibrillation (5% vs. 13%, p=0.031), prolonged air leak (8% vs 16%, p=0.044), any complication (28% vs. 44%, p=0.007), and LOS (5.0 vs. 5.98 days, p=0.031) was noted for women. In multivariate analysis, which included age, pack years and FEV1%, male sex remained a significant predictor for the occurrence of a post-operative complication (p= 0.007). Figure 1

      Conclusion
      Sex-based differences in the morbidity associated with resection for NSCLC were noted, with a significant improvement in several important short –term outcomes for women compared to men. As the percent of female NSCLC patients increase, these data carry significant implications in procedural risk stratification and in comparison of modern surgical trials to historic controls.