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• 12495

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  P3.07 - Poster Session 3 - Surgery (ID 193)

  • Event: WCLC 2013
  • Type: Poster Session
  • Track: Surgery
  • Presentations: 1
  • Moderators:
  • Coordinates: 10/30/2013, 09:30 - 16:30, Exhibit Hall, Ground Level

  • 12511

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    P3.07-016 - Clinical Impact of Postoperative Cardio-pulmonary Complications on Long-term Outcome in Lung Cancer Patients (ID 1494)

    09:30 - 09:30  |  Author(s): T. Nojiri
    • Abstract

    Background
    Postoperative cardiopulmonary complications represent a major source of morbidity and mortality in the acute phase after lung cancer surgery. However, clinical impacts of postoperative cardiopulmonary complications on long-term outcome were not well studied. The objective of this study was to investigate the effects of postoperative cardiopulmonary complications in the acute phase on cardiovascular and respiratory events in the chronic phase after lung cancer surgery.

    Methods
    From a prospective single-institution database of 496 consecutive patients who underwent a lung cancer surgery between August 2008 and December 2011, we retrospective analysed medical charts of all patients with curative surgery for non-small cell lung cancer. Patients with limited surgery (n=32) and postoperative mortality (n=4) were excluded from the analysis. The remaining 460 patients were analysed for the incidence of cardiovascular and respiratory events in the chronic phase after surgery. Results were compared between the patients with and without postoperative cardiopulmonary complications in the acute phase.

    Results
    Postoperative cardiopulmonary complications were identified in 90 (20%) patients; these patients included more advanced patients with pathological stage IB-III compared to those without cardiopulmonary complications (60% vs. 48%; p < 0.05). There were significantly higher cardiovascular and respiratory events in those with postoperative cardiopulmonary complications than those without (Table 1, 14% vs. 4%; p < 0.001). Also, there was significantly higher incidence of cancer recurrence in those with postoperative cardiopulmonary complications than those without (27% vs. 20%; p < 0.05).

    Table 1. Cardiovascular and respiratory events in the chronic phase for the patients with and without postoperative cardiopulmonary complications in the acute phase after lung cancer surgery.

    Variables	With cardiopulmonary complications (N=90)	Without cardiopulmonary complications (N=370)	P Value
    All events	13 (14%)	14 (4%)	<0.001
    Cardiovascular events	7 (8%)	7 (2%)
    Acute heart failure	3	1
    Arrhythmias	1	2
    Coronary artery disease	0	3
    Peripheral vascular disease	2	0
    Cerebrovascular disease	1	1
    Respiratory events	6 (7%)	7 (2%)
    Pneumonia	5	6
    Acute respiratory distress syndrome	0	1
    Chronic respiratory failure	1	0

    Conclusion
    Postoperative cardiopulmonary complications in the acute phase were associated with the incidence of cardiovascular and respiratory events in the chronic phase after lung cancer surgery. It is important for those with postoperative cardiopulmonary complications to be careful about not only cancer recurrence but also cardiovascular and respiratory events in the long-term period.