Author of

• 11917

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  P2.21 - Poster Session 2 - Diagnosis and Staging (ID 170)

  • Event: WCLC 2013
  • Type: Poster Session
  • Track: Prevention & Epidemiology
  • Presentations: 1
  • Moderators:
  • Coordinates: 10/29/2013, 09:30 - 16:30, Exhibit Hall, Ground Level

  • 11928

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    P2.21-011 - Persistent Ground-Glass Opacity Lung Nodules < 20 mm in Diameter at CT: Histopathologic Comparisons with imaging features (ID 2357)

    09:30 - 09:30  |  Author(s): J. Shi
    • Abstract

    Background
    Differentiation of atypical adenomatous hyperplasia (AAH), adenocarcinoma in situ (AIS), minimally invasive adenocarcinoma (MIA), and invasive adenocarcinoma(IA) on computed tomography (CT) is useful for determining ‘‘follow-up or resection’’ strategies for lesions displaying ground-glass opacity nodules(GGN). The purpose of this study is to compare the morphologic features of persistent GGNs of <20 mm in diameter at thin-section CT (TSCT) with histopathology.

    Methods
    Jan 2010 and Dec 2012, a total of 200 nodules in 191 resected GGNs that were evaluated with TSCT were included in this study. Correlations between histopathology and CT characteristics were examined.

    Results
    The nodules included 45 AAH (22.5%), 99AISs (49.5%), 11 MIAs (5.5%), and 45 invasive adenocarcinomas (22.5%). The mean CT value (P < .0001), size of nodule (P < .0001) were significant factors that differentiated AAH lesions from invasive adenocarcinoma or AIS or MIA. While the size of nodule (P < .0001) and mass of nodule (P < .0.001) were significant factors that differentiated invasive adenocarcinoma from AIS or MIA.

    Conclusion
    Size of nodule less than 10 mm and mean CT value less than -510Hu are determinants of AAH, while size and mass of the nodule are determinants of invasive adenocarcinoma in Chinese population.