Author of

• 11905

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  P2.20 - Poster Session 2 - Early Detection and Screening (ID 173)

  • Event: WCLC 2013
  • Type: Poster Session
  • Track: Imaging, Staging & Screening
  • Presentations: 1
  • Moderators:
  • Coordinates: 10/29/2013, 09:30 - 16:30, Exhibit Hall, Ground Level

  • 11906

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    P2.20-001 - Effect of repeated annual sputum cytology screening on high risk population: change of incidence of squamous cell carcinoma (ID 278)

    09:30 - 09:30  |  Author(s): Y. Saito
    • Abstract

    Background
    Sputum cytology is a widely accepted non-invasive diagnostic method for lung cancer. However, the efficacy to reduce lung cancer mortality has not been clearly proven in mass screening setting. To understand the potential value of sputum cytology to detect squamous cell carcinoma (SCC) of the lung, we evaluated its sensitivity and specificity. We simultaneously attempted to clarify the effect of repeated screening on the incidence of SCC.

    Methods
    In total, 104,872 sputum cytology tests combined with miniature chest X-ray were performed on 44,809 people belonging to the high-risk population of Miyagi Prefecture in Japan from 1990 to 1996. The sensitivity and specificity were calculated based on the information from the Cancer Registry. The incidence of SCC in the year after sequential annual repeat or sequential annual absences was analyzed.

    Results
    In total, 183 SCC-positive cases were diagnosed. The sensitivity and specificity of sputum cytology for SCC were 66.7% and 99.9%, respectively. Among cases with known localization, sensitivity for the central type was 90.7%, while that for peripheral type was 64.2%. Similarly, significantly decreased screen-detected SCC was observed in the third repeated test . A significant increase in screen-detected SCC cases was observed in the third year of sequential absence from screening.

    Conclusion
    Annual screening by sputum cytology for the high-risk group showed high sensitivity for SCC of the lung, particularly for central type SCC. Significantly reduced incidence of central type SCC was observed by repeating annual sputum cytology screening.