Author of

• 11842

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  P2.15 - Poster Session 2 - Thymoma (ID 191)

  • Event: WCLC 2013
  • Type: Poster Session
  • Track: Thymoma & Other Thoracic Malignancies
  • Presentations: 1
  • Moderators:
  • Coordinates: 10/29/2013, 09:30 - 16:30, Exhibit Hall, Ground Level

  • 11850

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    P2.15-008 - Comparison of outcomes after extended thymectomy for myasthenia gravis by presence of thymoma (ID 3050)

    09:30 - 09:30  |  Author(s): Y. Ozeki
    • Abstract

    Background
    Thymoma occurs in about 10-20% of myasthenic patients and in turn, 20-25% of patients with a thymoma have myasthenia gravis. The patients with myasthenia gravis are treated by extended thymectomy. The aims of this study were to analyze the clinical outcomes of myasthenic patients after extended thymectomy by presence of thymoma.

    Methods
    Forty one patients with myasthenia gravis (27 patients without thymoma: Group A and 14 patients with thymoma: Group B) underwent extended thymectomy between 1995 and 2013. In patients with thymoma, the WHO histological classification was: A in 2 cases, B1 in 3, B2 in7, and B3 in 2. The Masaoka clinical staging was: I in 4 cases, II in 7, IVa in 3. A change of clinical manifestation was examined with QMG score. Reduction of anti-acetylcholine receptor antibody titer (anti-AchR) was evaluated before and at 3 months after thymectomy.

    Results
    Mean follow-up period was 8.7 years (range, 0.3 to 17.8). The frequency of postoperative re-aggravation was significantly high in group B (5/14) in comparison with group A (1/27). The anti-AchR were reduced from 170.9 to 76.7 (p=0.029) in Group A, and were increased from 22.4 to 35.8 (n.s.) in Group B. Re-elevation of anti-AchR after surgery was recognized to 7.4% (2/27) in Group A and 42.9% (6/14 ) in Group B, respectively.

    Conclusion
    These data suggest that extended thymectomy for myasthenia gravis is more effective in patients without thymoma than in those with thymoma.