Author of

• 11842

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  P2.15 - Poster Session 2 - Thymoma (ID 191)

  • Event: WCLC 2013
  • Type: Poster Session
  • Track: Thymoma & Other Thoracic Malignancies
  • Presentations: 1
  • Moderators:
  • Coordinates: 10/29/2013, 09:30 - 16:30, Exhibit Hall, Ground Level

  • 11848

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    P2.15-006 - Retrospective study on the efficacy of multidisciplinary therapy for thymic cancers (ID 2259)

    09:30 - 09:30  |  Author(s): M. Hashimoto
    • Abstract

    Background
    Thymic cancer is relatively rare malignant disease, and the therapeutic strategy remains to be explored. The purpose of this study is to evaluate the clinical features of thymic cancers after multidisciplinary therapy.

    Methods
    From January 2004 to December 2012, 13 patients were diagnosed with thymic cancer in our hospital. Clinical features of 12 cases except 1 case who was given best supportive care from the beginning were evaluated retrospectively.

    Results
    The mean age of patient was 62 years old, ranging 41 to 79 years old. Stages of tumors according to Masaoka staging system were as follows; the number of patients with stages 1/2/3/4A/4B was 1/2/4/0/5, respectively. The pathological subtypes of the tumor according to the WHO histological criteria included squamous cell carcinomas in 7 cases, adenocarcinomas in 3, large cell neuroendocrine carcinoma (LCNEC) in 1 and undifferentiated carcinoma in 1. Of 12 patients, 6 patients (50.0%) underwent complete resection of both tumor and thymic tissues (Surgery group, the number of patients with stage 1/2/3/4A/4B=1/2/2/0/1) and others (50.0%) received chemo-radiotherapy (Non-surgery group, the number of patients with stage 1/2/3/4A/4B = 0/0/2/0/4). In Surgery group, 5 patients (83.3%) received adjuvant radio- or chemotherapy. Despite of multidisciplinary therapy, recurrences of the tumor were observed in 2 cases (33.3%) with pathological subtypes of adenocarcinoma and LCNEC. The median disease free survival after surgery in Surgery group was not reached at the time of this analysis. Kaplan-Meier analysis revealed that the median survival times after the treatment in Surgery and Non-surgery groups were 53.0 and 18.0 months, respectively, indicating that patients in Surgery group had significant longer survival than those in Non-surgery group (P=0.049, log-lank test).

    Conclusion
    Multidisciplinary therapy including complete resection of tumors can achieve better therapeutic outcomes. Non-squamous cell carcinomas are likely to be subtypes with poor prognosis despite of multidisciplinary therapy.