Author of

• 11745

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  P2.11 - Poster Session 2 - NSCLC Novel Therapies (ID 209)

  • Event: WCLC 2013
  • Type: Poster Session
  • Track: Medical Oncology
  • Presentations: 1
  • Moderators:
  • Coordinates: 10/29/2013, 09:30 - 16:30, Exhibit Hall, Ground Level

  • 11776

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    P2.11-031 - Radiofrequency ablation of liver metastases may prolong the survival of pulmonary adenocarcinoma patients with liver metastasis (ID 2249)

    09:30 - 09:30  |  Author(s): Y. Chiou
    • Abstract

    Background
    In patients with non-small cell lung cancer (NSCLC), the development of liver metastasis (LM) is a poor prognostic factor that compromises survival time. Whether combine systemic treatment with local treatment for liver metastases has benefit for NSCLC patients with LM is unknown. How to select a suitable patient for receiving local treatment is also unclear.

    Methods
    We retrospectively reviewed 713 pulmonary adenocarcinoma patients and 85 patients that developed LM at any time point in the course of the disease were identified for analysis. We use radiofrequency ablation (RFA) for local treatment of liver metastases. The indication of RFA were liver metastases number less than three with maximal size less than 5cm. RFA was performed with real-time ultrasonography guidance. Dynamic computed tomography (CT) scan was done 1 month after RFA for evaluating local therapeutic efficacy. An SPSS version 19 statistical software package (SPSS INC, Chicago, IL, USA) was used for data analysis.

    Results
    The independent prognostic factors after LM were Performance status、epidermal growth factor receptor (EGFR) mutation and LM numbers. There were 47 patients (54.7%) have LM nodules number less than three. The median overall survival (OS) in patients with LM nodules number less than three was 7.9 months comparing with 2.9 months in patients with nodules number over three ( P < 0.001). The independent prognostic factors for LM nodules number less than three patients were performance status and presence of brain metastasis. There were total six patients received RFA. Patients who received RFA treatment had better median OS after LM than those not ( 19.1 v.s 6.0 months, P = 0.04)

    Conclusion
    We recommend patients with better performance status (ECOG <2) without brain metastasis can consider RFA for liver metastases.