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A. Ozet



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    P2.06 - Poster Session 2 - Prognostic and Predictive Biomarkers (ID 165)

    • Event: WCLC 2013
    • Type: Poster Session
    • Track: Biology
    • Presentations: 1
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      P2.06-006 - Clinical and Prognostic Importance of XIAP and USP8 in Advanced Stages of Non-Small Cell Lung Cancer (ID 669)

      09:30 - 09:30  |  Author(s): A. Ozet

      • Abstract

      Background
      Apoptotic pathways are controlled by activation or inhibition of the intracellular caspases. Inhibitor of apoptosis proteins (IAPs) are endogenous inhibitors of caspase activity. We aimed to investigate the relationship of the apoptosis regulators X-linked inhibitor of apoptosis (XIAP) and ubiquitin specific protease 8 (USP8) with clinical parameters, survival and response to chemotherapy in advanced stages of non-small cell lung cancer (NSCLC).

      Methods
      A total of 34 NSCLC patients (28 males, 6 females) and 44 healthy volunteers were included in the study. Most of the patients had squamous cell histology (62%), while others had adenocarcinoma (29%) and unclassified (8%) types. All patients had locally advanced stage IIIA-IIIB (50%) or metastatic (50%) disease. XIAP and USP8 levels were measured by ELISA method.

      Results
      The median serum XIAP levels were similar in patients and the controls (p=NS). USP8 level was higher in patients compared to the control group (p<0.0001). In univariate analysis, there was no significant relationship between XIAP and USP8 serum levels and age, sex, performance status, weight loss, stage of disease, histopatological type and response to chemotherapy. In the low and high XIAP and USP8 groups, there was no significant difference in progression-free survival (PFS) (p=0.432 and p=0.50, respectively) and overall survival (OS) (p=0.989 and p=0.90, respectively).

      Conclusion
      No relationship was found with serum XIAP and USP8 levels and clinical parameters, response to chemotherapy, PFS and OS in patients with advanced stages of NSCLC.