Author of

• 10850

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  P1.12 - Poster Session 1 - NSCLC Early Stage (ID 203)

  • Event: WCLC 2013
  • Type: Poster Session
  • Track: Medical Oncology
  • Presentations: 1
  • Moderators:
  • Coordinates: 10/28/2013, 09:30 - 16:30, Exhibit Hall, Ground Level

  • 10873

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    P1.12-023 - Predictive factors of recurrence in lepidic predominant lung adenocarcinoma (ID 3454)

    09:30 - 09:30  |  Author(s): J. Hung
    • Abstract

    Background
    The new International Association for the Study of Lung Cancer, American Thoracic Society and European Respiratory Society (IASLC/ATS/ERS) lung adenocarcinoma classification has been proposed in 2011. The aim of the study is to demonstrate the prognostic factors and pattern of recurrence in lepidic predominant lung adenocarcinoma.

    Methods
    We retrospectively reviewed 545 patients undergoing surgical resection for lung adenocarcinoma in Taipei Veterans General Hospital between 2006 and 2010. Fifty-two patients with lepidic predominant lung adenocarcinoma were identified. The predictive factors and pattern of recurrence of these patients were investigated.

    Results
    The 5-year overall survival and recurrence-free rates were 84.0% and 83.0%, respectively. During follow-up, 7 (13.5%) patients developed recurrence. The median time to recurrence was 28.7 months (range, 10.6 to 57.8 months). The percentage of T2-4 (P = 0.003), N1-2 (P < 0.001), TNM stage II-III (P < 0.001), and visceral pleural invasion (P = 0.049) was significant higher in patients with recurrence. N status (N1-2 vs. N0) (P < 0.001), TNM stage (II-III vs. I) (P < 0.001) were significant prognostic factors of freedom from recurrence in univariate analysis. Visceral pleural invasion (P = 0.093) and presence of solid pattern (P = 0.089) tended to be significant prognostic factors of freedom from recurrence in univariate analysis. TNM stage (II-III vs. I) (P = 0.005) was still a significant predictive factor of freedom from recurrence in multivariate analysis. Figure 1

    Conclusion
    The overall survival and freedom from recurrence rates were good in lepidic predominant adenocarcinoma. TNM stage (II-III vs. I) was a significant predictive factor of freedom from recurrence in these patients.

• 12701

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  P3.12 - Poster Session 3 - NSCLC Early Stage (ID 206)

  • Event: WCLC 2013
  • Type: Poster Session
  • Track: Medical Oncology
  • Presentations: 1
  • Moderators:
  • Coordinates: 10/30/2013, 09:30 - 16:30, Exhibit Hall, Ground Level

  • 12726

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    P3.12-025 - Survival in octogenarians with pathological stage I non-small cell lung cancer patients underwent complete resection (ID 3319)

    09:30 - 09:30  |  Author(s): J. Hung
    • Abstract

    Background
    For patients older than 80 years old, surgical treatments for resectable lung cancer were usually to a limited extent, or even not considered. Few studies evaluated the true effect of surgery for these patients. The aim of this study is to compare the survival between the octogenarians and younger patients with pathological stage I non-small cell lung cncer (NSCLC) underwent complete resection using multivariate analysis.

    Methods
    The clinicopathological characteristics of 870 patients underwent complete resection of stage I NSCLC between Jan. 2002 and Dec. 2011 were retrospectively reviewed. The patients were categorized as octogenarians (aged 80~90) or younger (aged < 80). Survival under multivariate analysis was examined.

    Results
    76 (8.7%) octogenarians were indentified in the 870 patients, average age was 82.4±2.5 years old. The 794 younger patients had average age of 63.0±10.4. Pulomany function test including forced expiratory volume in one second (FEV~1~) and FEV~1~/ forced vital capacity (FVC) were 1.80±0.44 L and 70.5±11.7 % in the elder group, and were 2.23±0.59 L and 76.3±9.9% in the younger patients (p < 0.001). There were 44 (57.9%) lobectomies and 32(42.1%) sublobar resections performed for the octogenarians, while 689 (86.8%) lobectomies and 94(11.8%) wedge resections/segementectomies were done for the younger patients (p < 0.001). Average tumor size was 2.6±1.15 cm and 2.4±1.12 cm, respectively (p = 0.076). Five surgical mortalities were found, 2 (2.63%) were in the elder group and 3 (0.37%) were in the younger group. The overall 5-year survivals of the two groups were 64.9% and 76.9%, respectively (p = 0.015). Under multivariate analysis, male sex, extension of resecion, FEV~1~ and tumor T-status associated with poorer survival. Older than 80 years old didn’t associated with difference in survival (p = 0.911). Figure 1

    Conclusion
    Octogenarians with pathological stage I NSCLC underwent complete surgical resection had similar survival with their younger counterparts. Although they usually had poorer lung function, thus received more wedge resections or segmentectomies, aggressively performing surgical resectionon the elder ones would have similar benefits as on the younger ones.