Virtual Library

 x 
My Library Virtual Library FAQ

Start Your Search

J. Kim



Author of

  • +

    P1.11 - Poster Session 1 - NSCLC Novel Therapies (ID 208)

    • Event: WCLC 2013
    • Type: Poster Session
    • Track: Medical Oncology
    • Presentations: 1
    • +

      P1.11-015 - The prognostic value of total number of harvested lymph nodes and nodal ratio in node positive Non-small cell lung cancer (ID 1379)

      09:30 - 09:30  |  Author(s): J. Kim

      • Abstract

      Background
      The purpose of this study is to evaluate the prognostic value of nodal ratio (NR) and total number of harvested lymph nodes (HLN) in postoperatively node positive Non-small-cell lung cancer (NSCLC).

      Methods
      Between June 2003 and December 2010, 1192 NSCLC patients had undergone surgical resection at Seoul National University Bundang Hospital. In this study, we excluded patients who had preoperative adjuvant treatments and were revealed to have pathologic T4, N3 or M1. Total 240 patients with N1 or N2 disease were analyzed in this study. According to the number of HLN and NR, we evaluated disease-free survival (DFS), locoregional recurrence-free survival (LRRFS), distant metastasis-free survival (DMFS) and overall survival (OS).

      Results
      The median follow-up time was 36 months for the surviving patients and median total number of HLN was 23 (range, 6-64). On univariate analysis, patients with more than 20 HLN showed better 3-year DFS (55.6% vs 46.4% p = 0.045) and OS (78.2% vs 61.1%, p = 0.058), respectively. Patients who had NR > 0.1 showed worse 3-year DFS (39.3% vs 64.4%, p = 0.045), LRRFS (72.8% vs 84.0%, p = 0.037), DMFS (45.5% vs 69.6%, p < 0.001) and OS (62.9% vs 79.8%, p = 0.067), respectively. On multivariate analysis, NR > 0.1 showed statistical significance in 3-year LRRFS (p = 0.009) and marginal statistical significance in DFS (p = 0.083) and OS (p = 0.068).

      Conclusion
      The current nodal classification system does not include the total number of HLN and NR. The results of this study suggest that the total number of HLN and NR could be regarded as important prognostic factors and these factors might be used as decision criteria to postoperative adjuvant radiotherapy for patients with operable NSCLC.