Author of

• 10743

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  P1.10 - Poster Session 1 - Chemotherapy (ID 204)

  • Event: WCLC 2013
  • Type: Poster Session
  • Track: Medical Oncology
  • Presentations: 1
  • Moderators:
  • Coordinates: 10/28/2013, 09:30 - 16:30, Exhibit Hall, Ground Level

  • 10751

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    P1.10-008 - Clinical Significance of Hyperpigmentation due to Pemetrexed Treatment in Advanced Non-Squamous Non-small cell lung cancer in China (ID 719)

    09:30 - 09:30  |  Author(s): Q. Hu
    • Abstract

    Background
    Previous publications have demonstrated the efficacy of pemetrexed (PEM) as first-line, second-line and maintenance therapy in advanced non-small cell lung cancer (NSCLC). A recent study found skin toxicities compromised continuation of PEM treatment. The purpose of this study is to investigate the clinical significance of hyperpigmentation (HP) in advanced non-squamous (NS) NSCLC receiving PEM-based therapy in China.

    Methods
    Medical records of patients with advanced NS NSCLC who received PEM-based treatment in our hospital were retrospectively studied. Chi-square test, Pearson’s test as well as Kaplan-Meier method and Cox Proportional Hazards model were performed for statistical analysis.

    Results
    A total of 101 patients were collected with a median age of 58 years old. Among them, 53 (52.5%) were female and 65 (64.4%) were nonsmokers. 52 (51.5%) patients received first-line treatment. Presence of HP was associated with better ORR (22% vs 7.1%, p=0.043), higher DCR (84.7% vs 54.8%, p=0.001), and had longer PFS (186 days versus 96 days, p<0.0001). There were no significant differences according to grade of HP in ORR, DCR and PFS. There was a higher incidence of hyperpigmentation in patients who received first-line treatment (73.1%% vs 42.9%, p=0.023) and doublet chemotherapy (43.1% vs 74.0%, p=0.002). However,multivariate analysis demonstrated HP was not an independent factor for better clinical outcomes (vs absence, Hazard Ratio [HR] 0.417, 95% Confidential Interval [CI] 0.255-0.690, p=0.493).

    Conclusion
    HP due to PEM is frequent in advanced NS NSCLC receiving PEM. It might be a predictive factor for better clinical outcomes in Pemetrexed-treated advanced NS NSCLC in China.